Center for Functional MRI In the Department of Radiology

Faculty Research

Dr. Divya Bolar


  • Developing and applying novel MRI techniques to noninvasively image cerebral physiology.
  • Advancing velocity-based spin labeling methodology to measure cerebral perfusion, oxygen metabolism, and blood-brain barrier permeability, for use in stroke, steno-occlusive disease, and neurodegenerative disorders.
  • Holds US patent for QUIXOTIC MRI, a novel approach to quantitatively map cerebral oxygen extraction and metabolism, and has recently introduced VESPA ASL, a method to simultaneously image cerebral blood flow and arterial transit times.
Dr. Bolar Publications

Dr. Richard Buxton


  • Neural activity, blood flow and energy metabolism in the human brain.
  • Combining arterial spin labeling (ASL) methods with blood oxygenation level dependent (BOLD) methods to estimate changes in brain oxygen metabolism in response to a stimulus or a drug.
  • Mathematical modeling of imaging methods, the BOLD effect, and oxygen transport from blood to tissue.
  • Application of ASL methods to measure dynamic blood flow changes in the lung.
Dr. Buxton Publications

Dr. David Dubowitz


  • Basic physiology of functional MRI, both in humans and in other animals.
  • MRI measurements of cerebral blood flow and metabolism, particularly as they apply to acclimatization and de-acclimatization to hypoxia at altitude.
  • MRI measurements of pulmonary blood flow.
  • Magnetic resonance spectroscopy (MRS).
Dr. Dubowitz Publications

Dr. Lawrence Frank
  • Development of pulse sequence and data analysis methods for diffusion tensor imaging with a view towards the quantitative assessment of the structure and physiology of tissues, with particular emphasis on white matter disease and musculoskeletal applications. 
  • Real-time reconstruction and noise correction methods for functional MRI applications. 
  • Applications of arterial spin labeling method to the study of muscle function and physiology. 

Dr. Frank Publications

Dr. Thomas Liu
  • Investigation of resting-state brain connectivity with multi-modal imaging approaches (fMRI, MEG, and EEG).
  • Characterization and modeling of the hemodynamic response to neural activity, including the effects of drugs such as caffeine.
  • Development and optimization of arterial spin labeling MRI methods for the non-invasive measurement of cerebral blood flow.
  • Design and analysis of experiments for functional MRI (fMRI), with an emphasis on statistical optimization, nonlinear signal processing, and physiological noise reduction.
  • Development of quantitative fMRI methods for the study of Alzheimer’s disease and associated disorders.
Dr. Liu Publications

Dr. Miriam Scadeng


  • Development of novel small animal imaging techniques over a wide range of organ systems and species, including mechanisms of traumatic brain injury, methods for high resolution MRI of the lungs, anatomical and physiological studies in marine mammals and diving birds.
  • Development of ontologoical MRI atlases of development in the common animal models used in biomedical research, particularly mice, zebrafish and chickens.

Dr. Scadeng Publications

Dr. Samuel Ward

  • Skeletal muscle design and plasticity with special emphasis on the shoulder, spine, and knee. 
  • Emphasis on multimodal imaging (X-Ray, CT, MRI, PET, ultrasound, bioluminescence, and microscopy) of skeletal muscle in animal and human models studies. 
  • A key initiative for Dr. Ward’s lab is to understand skeletal muscle microstructure and physiology using MRI.

Dr. Ward Publications

Dr. Eric Wong


  • Arterial Spin Labeling techniques for noninvasive measurement of tissue perfusion.
  • High speed and high resolution imaging techniques, including spiral techniques and contrast optimization.
  • Diffusion imaging.
  • Local gradient coils.
  • Application specific RF coils.
  • Local shim coils.
Dr. Wong Publications